On December 1st and 2nd 2020, EPICLUSTER’s second activity took place. On the first day, the EPICLUSTER leadership and wider stakeholder group met for a workshop on funding. On the second day, EPICLUSTER organised and ran EpiXchange II, a community-building meeting based on the format of EpiXchange I (2018). The meeting brought together various FP7 and Horizon 2020 epilepsy projects with stakeholders to review progress and future directions in key research areas including genetics, biomarkers, therapeutics, co-morbidities and biobanks/resources.