The primary objective the Trisomy 21 cluster is to establish a collaborative framework for the coordinated actions of Down syndrome research in Europe. Through EBRA cluster, we wish to expand existing European networks to promote coordination and collaboration among European scientists belonging to these research networks and share common projects with the goal of understanding disorders of the developing brain leading to intellectual disabilities such as DS.

The Trisomy 21 cluster aims at:

  • Expand the network of DS researchers and initiate collaborative research on other intellectual disabilities and Alzheimer’s disease.

  • Harmonize and standardize protocols for DS (pre)clinical research, enabling better comparisons among studies.

  • Co-ordinate efforts with research strategies across European and global brain initiatives.

  • Enhance resource-sharing (experimental models, IPSc, clinical protocols, etc.).

  • Develop a preclinical network and enhance clinical trial structures.

  • Increase engagement in research of persons with Down syndrome and their representatives.

  • Promote research on Down syndrome and Intellectual Disabilities by developing a funding initiative across agencies.

  • Increase the visibility of the Down syndrome research community.

The Trisomy 21 EBRA cluster is composed of centres of excellence in Neuroscience in seven different European countries (Belgium, France, Italy, Spain, Switzerland, The Netherlands and UK) with 20 scientists and the exact gender balance. Members will be both senior and mid-carrier researchers and clinicians. The minimal list of members with their institute and country of origin is listed below.

A series of four events will be run

European College of Neuropsychopharmacology (ECNP) network:

The TRISOMY21 cluster is also involved in the ECNP network: The Down Syndrome and other Genetic Developmental Disorders (DSG2D).

ECNP Networks bring together researchers with different expertise across Europe to foster successful collaboration and sharing of ideas, discoveries and practices in translational neuroscience. The overarching aim of ECNP Networks is to facilitate the collection of essential biological, clinical and therapeutic data in a standardised way to guarantee their robustness, reproducibility and translatability.

Interested in TRISOMY21-CLUSTER? Please contact ebra@braincouncil.eu for more information.